In hypertensive patients, Sotalol produces significant reductions in both systolic and diastolic blood pressures. Exercise and isoproterenol induced tachycardia are antagonized by Sotalol, and total peripheral resistance increases by a small amount. Mean arterial pressure, mean pulmonary artery pressure and stroke work index did not significantly change. One patient was discontinued because of worsening congestive heart failure. Pulmonary capillary wedge pressure increased significantly from 6.
Both the Class III and beta-blocking effects of Sotalol were linearly related with the plasma concentrations. No significant alteration in QRS interval is observed. The Class III electrophysiological effects in man include prolongation of the atrial and ventricular monophasic action potentials, and effective refractory period prolongation of atrial muscle, ventricular muscle, and atrio-ventricular accessory pathways where present in both the anterograde and retrograde directions. In man, the Class II beta-blockade electrophysiological effects of Sotalol AF are manifested by increased sinus cycle length slowed heart ratedecreased AV nodal conduction and increased AV nodal refractoriness. In intact animals it slows heart rate, decreases AV nodal conduction and increases the refractory periods of atrial and ventricular muscle and conduction tissue. Sotalol hydrochloride prolongs the plateau phase of the cardiac action potential in the isolated myocyte, as well as in isolated tissue preparations of ventricular or atrial muscle Class III activity. Although significant beta-blockade occurs at oral doses as low as 25 mg, significant Class III effects are seen only at daily doses of mg and above. Sotalol does not have partial agonist or membrane stabilizing activity. Both isomers have similar Class III antiarrhythmic effects, while the l-isomer is responsible for virtually all of the beta-blocking activity. Sotalol AF is a racemic mixture of dand l-Sotalol. Sotalol hydrochloride is a white, crystalline solid with a molecular weight of It is hydrophilic, soluble in water, propylene glycol and ethanol, but is only slightly soluble in chloroform.Ĭhemically, Sotalol hydrochloride is d,l- N -ethyl]phenyl]methanesulfonamide monohydrochloride. It is supplied as a white, capsule-shaped tablet for oral administration. Sotalol hydrochloride tablets, however, should not be substituted for Sotalol hydrochloride tablets AF because of significant differences in labeling i. Last updated on Feb 1, To minimize the risk of induced arrhythmia, patients initiated or re-initiated on Sotalol Hydrochloride Tablets AF should be placed for a minimum of three days on their maintenance dose in a facility that can provide cardiac resuscitation, continuous electrocardiographic monitoring and calculations of creatinine clearance.
Generic Name: Sotalol hydrochloride Dosage Form: tablet.